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"It's a tough transition," Clapper said

If you do that enough, you can cause abnormal proliferation of the cells, said Dr John Frew, who is a dermatologist at Liverpool Hospital and Conjoint Senior Lecturer at UNSW Medicine & Health

Linaclotide for irritable bowel syndrome with constipation: a 26-week, randomized, double-blind, placebo-controlled trial

This risk is particularly pronounced when combined with insulin or sulfonylureas