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Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin
Science 309 , 15771581 (2005)
The safety and effectiveness of VYVANSE for the treatment of obesity have not been established [see Warnings and Precautions (5.2)]
Elevated IL-6 and TNF-alpha suppress leptin signaling and impair hypothalamic satiety circuits, meaning inflamed individuals experience constant hunger despite adequate calorie intake
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