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Further, MTX increased the expression of PERK (Figure 6B), GRP78 (Figure 6C), ATF4 (Figure 6D), and CHOP-10 (Figure 6E) in the liver compared to CTRL, indicating that ER stress is implicated in MTX-induced hepatotoxicity
The interest and use of nutraceuticals that can play a supportive role in health and skin aging has increased dramatically in the last 10 years, with products containing vitamin C and E, collagen, omega-3 fatty acids, and antioxidants such as curcumin, glutathione, and resveratrol, which have multiple anti-inflammatory, protective effects against oxidative stress and age-related decline in cellular function [79,80,81]
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