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Leukemia stem cell marker CD123 (IL-3R alpha) predicts minimal residual disease and relapse, providing a valid target for SL-101 in acute myeloid leukemia with FLT3-ITD mutations

Overall, it would appear that the abundance of GSTs and their predominantly high activity with JS-K would cause the rapid biotransformation of the prodrug in most tissues

doi:10.2147/DDDT.S166765 Drucker DJ

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It was also linked to cancer, vision loss, and a host of other chronic conditions