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2019;35:17790.e8
If You Have An Active Skin Condition Like Acne Or Eczema Tranexamic acid may make inflammatory skin conditions like eczema, acne or psoriasis worse
Patients should be counseled to: Consume smaller, more frequent meals (56 per day) rather than large portions Emphasize low-fat, low-fiber foods that empty more readily from the stomach Ensure adequate hydration, particularly with liquid calories if solid food tolerance is poor Avoid lying down immediately after meals Chew food thoroughly and eat slowly For patients developing concerning symptoms, temporary dose reduction or treatment interruption may be necessary
In clinical trials, discontinuation rates due to gastrointestinal adverse effects ranged from 3-7%, indicating that whilst most patients can tolerate these symptoms, they can be sufficiently troublesome to necessitate treatment cessation in some cases
Several studies have demonstrated that in vitro heat stress has detrimental effects on various aspects of cytoplasmic and nuclear oocyte maturation 70 , including cytoskeletal rearrangement 14 , meiotic spindle formation 14,67 and early embryonic mitotic failure 71
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