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The immunoprecipitates were mixed with protein A-agarose beads (sc2003, Santa Cruz) and rotated for 2 h at 4 C
Interestingly, we transfected 293T cells with Myc-labeled ubiquitin, HA-labeled KEAP1, and Flag-labeled NRF2 plasmids and observed that the upregulation of KEAP1 promoted the poly-ubiquitination of NRF2, and SP could down-regulate the KEAP1 expression and block the NRF2 ubiquitination dose-dependently (Supplementary Fig
Its also even more interesting when you consider that most cases of hypothyroidism (Hashimotos thyroiditis) are also caused by autoimmune disease
not approved TB-500 Also removed from FDA Category 2 April 22, 2026
Shanghai Science and Technology Development Funds 18ZR1447800 (L.H.Z.) and 18431907100 (M.-W.W.)
