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GPER plays a pivotal role in the cardiovascular system, especially in womens cardiovascular health, by modulating vascular function, inflammatory responses, and metabolic processes [176]
acute conditions occurring with the risk of developing renal dysfunction, such as dehydration (with diarrhea, vomiting), fever, severe infectious diseases, hypoxia (shock, sepsis, renal infections, bronchopulmonary diseases)
This 3-6 fold increase in oxalate absorption is significant, especially if paired with a genetic susceptibility or with a high oxalate diet.[ref] Enteric hyperoxaluria is a metabolic disorder that is primarily due to increased absorption of dietary oxalates
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