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Wang B, et al

In clinical trials [2], the most common side effects were mild digestive issues, including: nausea diarrhoea vomiting constipation These symptoms were dose-related, usually mild to moderate, and often improved when the dose was increased more slowly

doi:10.1161/CIRCULATIONAHA.115.017719 Perkovic V, Tuttle KR, Rossing P, et al

To test this, we purified recombinant VadK (Fig