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The hormone was first identified in the 1980s when researchers discovered that oral glucose intake stimulated more insulin release than intravenous glucose administration, a phenomenon known as the incretin effect
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As they are highly reactive, ROS can react with and damage important molecules, such as DNA , lipids (such as those in cell membranes) and proteins (including key enzymes and structural proteins)
Among these, random mutagenesis techniques such as ultraviolet (UV) irradiation effectively generate phenotypic diversity without using recombinant DNA technology (Jeyachandran et al., 2024)
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