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However, since NO is freely diffusible across membranes, it is possible that the mitochondrial production of peroxynitrite may derive from extramitochondrial NO diffusing into mitochondria to react with superoxide generated by ETC

Resulting pooled event rates were 2.1 and 1.5 per 1000 patient-years of exposure, respectively, and the OR was 1.39 (95% CI 0.67, 2.88), suggesting a slightly elevated risk [58]

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Therefore, Pt-based inorganic nanosystems for tumor-specific delivery provide a prospective strategy to delay and even avoid the PIPN via reducing the accumulation of Pt drug in the peripheral nervous system