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It is approved for type 2 diabetes, but is used off-label for weight loss in overweight or obese patients under medical supervision
This could explain why tirzepatide (which stimulates the GIP pathway in addition to GLP -1) can be administered at higher doses than semaglutide (which only stimulates GLP-1), without amplifying the side effects typical of GLP-1 agonists (nausea, vomiting)
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