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Yu, W., Zhao, G
Treatment with 5-amino-1mq upregulates proliferationrelated genes (Ki67, PCNA), promotes cell cycle progression, and improves cell fusion efficiency to form more multinucleated myotubes, achieving functional levels similar to those of young mice.Additionally, 5-amino-1mq inhibits muscle stem cell apoptosis, reduces oxidative stress damage, and maintains stemness
Concurrently, lactate accumulation contributes to an acidic tumor microenvironment that impairs T cell effector function, induces exhaustion, and suppresses proliferation [83]
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